Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization
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چکیده
منابع مشابه
Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization
UNLABELLED The rodent arenavirus glycoprotein complex encodes a stable signal peptide (SSP) that is an essential structural component of mature virions. The SSP, GP1, and GP2 subunits of the trimeric glycoprotein complex noncovalently interact to stud the surface of virions and initiate arenavirus infectivity. Nascent glycoprotein production undergoes two proteolytic cleavage events: first with...
متن کاملRole of the stable signal peptide of Junín arenavirus envelope glycoprotein in pH-dependent membrane fusion.
The envelope glycoprotein of the arenaviruses (GP-C) is unusual in that the mature complex retains the cleaved, 58-amino-acid signal peptide. Association of this stable signal peptide (SSP) has been shown to be essential for intracellular trafficking and proteolytic maturation of the GP-C complex. We identify here a specific and previously unrecognized role of SSP in pH-dependent membrane fusio...
متن کاملRole of the Stable Signal Peptide of Junı́n Arenavirus Envelope Glycoprotein in pH-Dependent Membrane Fusion
The envelope glycoprotein of the arenaviruses (GP-C) is unusual in that the mature complex retains the cleaved, 58-amino-acid signal peptide. Association of this stable signal peptide (SSP) has been shown to be essential for intracellular trafficking and proteolytic maturation of the GP-C complex. We identify here a specific and previously unrecognized role of SSP in pH-dependent membrane fusio...
متن کاملThe signal peptide of the Junín arenavirus envelope glycoprotein is myristoylated and forms an essential subunit of the mature G1-G2 complex.
Arenaviruses comprise a diverse family of rodent-borne viruses that are responsible for recurring and emerging outbreaks of viral hemorrhagic fevers worldwide. The Junín virus, a member of the New World arenaviruses, is endemic to the pampas grasslands of Argentina and is the etiologic agent of Argentine hemorrhagic fever. In this study, we have analyzed the assembly and function of the Junín v...
متن کاملDissection of the role of the stable signal peptide of the arenavirus envelope glycoprotein in membrane fusion.
The arenavirus envelope glycoprotein (GPC) retains a stable signal peptide (SSP) as an essential subunit in the mature complex. The 58-amino-acid residue SSP comprises two membrane-spanning hydrophobic regions separated by a short ectodomain loop that interacts with the G2 fusion subunit to promote pH-dependent membrane fusion. Small-molecule compounds that target this unique SSP-G2 interaction...
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ژورنال
عنوان ژورنال: mBio
سال: 2014
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.02063-14